|
KMID : 0613820130230050616
|
|
Journal of Life Science
2013 Volume.23 No. 5 p.616 ~ p.621
|
|
|
Anti-aging and Anti-diabetes Effects of Aconitum pesudo-laeve var. erectum Extracts
|
|
Kim Jeung-Hoan
Lee Soo-Yeon
Kwon O-Jun
Park Joo-Hoon
Lee Jin-Young
|
|
|
Abstract
|
|
|
|
Aconitum pesudo-laeve var erectum has been known to possess anti-inflammatory activity and modulate the intestinal immune system. In addition, it has traditionally been used for the treatment of water retention in the body. In this study, the anti-aging and anti-diabetes effects of water and ethanol extracts from Aconitum pesudo-laeve var. erectum were investigated. The activities of each extract were measured by antioxidant tests such as DPPH and ABTS radical scavenging activity, antioxidant protection factor (PF), TBARs content, and α-amylase and α-glucosidase inhibition activity assay. DPPH radical scavenging activity was found in over 50% of water and ethanol extracts at 100μg/ml, 50μg/ml, respectively. The ABTS radical scavenging activity of ethanol extract was 99.8±0.1% at 1,000μg/ml in water, which was highest among the ethanol extract concentrations. PFs measured with β-carotene-linoleate model systems were in the order of ethanol (1.49 PF at 1,000μg/ml) > ethanol (1.40 PF at 500μg/ml) > water (1.33 PF at 1,000μg/ml) > water (1.27 PF at 500μg/ml). TBARs content in ethanol extracts (1,000μg/ml) was 0.16±0.03μM, which was lower than that of water extracts and other ethanol extract concentrations. The extracts also showed over 90% of α-amylase inhibition and over 60% of α-glucosidase inhibition ratio in water (1,000μg/ml) and ethanol extracts (100~1,000μg/ml). These results suggest that Aconitum pesudo-laeve var. erectum extracts could be used as a cosmetic source and preventive agent for aging and diabetes.
|
|
|
KEYWORD
|
|
|
Aconitum pesudo-laeve var. erectum, anti-oxidant, anti-diabetes, biological activity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|